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Keywords: Dietary fiber, Bone mineral density, bone loss, Sex-specific difference, Framingham Study Introduction Osteoporosis is a common skeletal disorder leading to increasing bone fragility and fracture risk that poses a substantial healthcare burden and affects physical function, comorbidity and mortality in both men and women with advancing age 1 , 2.

Dietary contributors to osteoporosis have focused on vitamin D and calcium, but nutrients beyond these 3 , 4 may also affect bone health. Intake of fruits and vegetables 5 and a fruit, vegetable and cereal pattern 6 in the Framingham cohorts have been suggested to be positively related to change in hip BMD in men but not in women. Even though these food sources are major contributors of dietary fiber, studies on dietary fiber per se are limited.

Recent experimental studies suggest that dietary fiber may benefit mineral absorption, BMD, and bone turnover 7 — 9. According to the Institute of Medicine, dietary fiber is defined as non-digestible carbohydrates and lignin that are intrinsic and intact in plants Studies have shown increased calcium absorption in rodent models treated with various fermentable dietary fiber 11 — Some 15 — 17 but not all 12 , 13 , 18 of these studies reported a positive effect on BMD.

The only cross-sectional observational study 21 , to our knowledge, reported that dietary fiber was positively related to forearm BMD in children but not in adolescents. However, results from clinical trials in postmenopausal women are inconsistent: Although a positive association has been shown between fiber intake and calcium absorption 22 — 25 , this does not translate to change in BMD 26 , Am J Hypertens. Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.

Hum Pathol. Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD. Psychiatry Res.

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Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells. Exp Eye Res. Trends Ecol Evol. J Virol Methods.

An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats.

Int J Cardiol. Identification of large disjoint motifs in biological networks. BMC Bioinformatics.

Mol Plant Microbe Interact. Epub Nov J Hum Genet. Epub Oct 6.

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Cell Rep. Ultradonut topology of the nuclear envelope. Factors affecting the success of a large embryo transfer program in Holstein cattle in a commercial herd in the southeast region of the United States. Epub Jun 2. The complex evolutionary history of big-eared horseshoe bats Rhinolophus macrotis complex : insights from genetic, morphological and acoustic data.

PLoS Genet. Curr Biol.

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Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. J Clin Periodontol. Epub Dec Tissue, developmental, and caste-specific expression of odorant binding proteins in a eusocial insect, the red imported fire ant, Solenopsis invicta.

Mol Ther Nucleic Acids. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med.

Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances.

Integr Environ Assess Manag.

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Trends Plant Sci. Non-toxigenic environmental Vibrio cholerae O1 strain from Haiti provides evidence of pre-pandemic cholera in Hispaniola. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Effects of four commercial fungal formulations on mortality and sporulation in house flies Musca domestica and stable flies Stomoxys calcitrans. Med Vet Entomol. Am J Psychiatry. Epub Nov 4. J Neurosci. Plant Physiol. Epub Nov 2. Epub Nov 3. Chilling-induced tomato flavor loss is associated with altered volatile synthesis and transient changes in DNA methylation.

Physiol Genomics. Epub Sep 9. Am J Trop Med Hyg. Paradoxical leanness in the imprinting-centre deletion mouse model for Prader-Willi syndrome.

J Endocrinol. Arthritis Care Res Hoboken.

Modification of embryonic resistance to heat shock in cattle by melatonin and genetic variation in HSPA1L. J Dairy Sci. Clinical response after chitosan microparticle administration and preliminary assessment of efficacy in preventing metritis in lactating dairy cows.

J Bacteriol.

Print Nov 1. A norovirus detection architecture based on isothermal amplification and expanded genetic systems. Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Epub Aug 9. Vaccinia virus dissemination requires pactivated kinase 1. Arch Virol.

Brain quantitative proteomic responses reveal new insight of benzotriazole neurotoxicity in female Chinese rare minnow Gobiocypris rarus. Epub Nov 1. Hum Gene Ther. Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.

BMC Evol Biol. Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina. Epub Nov 7. J Biol Chem.


Epub Oct 4. Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype. Acta Neuropathol Commun. Hum Gene Ther Clin Dev. Unravelling the genomic architecture of bull fertility in Holstein cattle. Epub Sep 3.

Distributions, abundances and activities of microbes associated with the nitrogen cycle in riparian and stream sediments of a river tributary. Water Res. Arsenic and phosphate rock impacted the abundance and diversity of bacterial arsenic oxidase and reductase genes in rhizosphere of As-hyperaccumulator Pteris vittata.

J Hazard Mater. Epub Sep 1. Inspiratory muscle conditioning exercise and diaphragm gene therapy in Pompe disease: Clinical evidence of respiratory plasticity. Interv Cardiol Clin. Implementation of inpatient models of pharmacogenetics programs.

Am J Health Syst Pharm. Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium PDC is not worse than in youth without diabetes. Sex differences in response of the bovine embryo to colony-stimulating factor 2.

Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration. In vivo tissue-tropism of adeno-associated viral vectors. Curr Opin Virol. Am J Hum Genet. The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity.

Genome editing of the disease susceptibility gene CsLOB1 in citrus confers resistance to citrus canker. Epub Jan 4. Mol Ther Methods Clin Dev.

Epub Dec 5.

If this has you feeling a little freaked out, fear not. Christopher is such a good guide that Stolen was a Printz Honor Book in So, you're in good hands.

Now, let's get twisted. Told in a letter to her captor by 16yearold Gemma, Stolen explores the influence that a really wild and remote space can have on the inner development of a young woman. Gemma, a British cityliving teenager, is kidnapped while on holiday with her parents. Her kidnapper, Ty, takes her to the wild land of outback Australia.

She's visited by a wide array of counselors, all of whom think she has Stockholm syndrome.The tale of the shrinking weapon: seasonal changes in nutrition affect weapon size and sexual dimorphism, but not contemporary evolution. Water Res. In the Framingham Offspring Study, at baseline — , diet was assessed using the Willett food frequency questionnaire and bone mineral density BMD was measured using dual-energy X-ray absorptiometry.

There is a total score, and individual integrated reasoning, verbal, quantitative, and analytical writing scores. Am J Trop Med Hyg.

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